反応 #1941721

ord-c002be7f985745408ad0fbc14731e4e5

反応方程式

CC(C)(C)C(=O)CNc1cc(C(=O)O)nn1-c1ccccc1
5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid
Cc1ccccc1[C@@H](N)CC(=O)O
(S)-3-Amino-3-o-tolyl-propionic acid
→
Cc1ccccc1[C@H](CC(=O)O)NC(=O)c1cc(NCC(=O)C(C)(C)C)n(-c2ccccc2)n1
(S)-3-{[5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

反応物

CC(C)(C)C(=O)CNc1cc(C(=O)O)nn1-c1ccccc1
5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid
Cc1ccccc1[C@@H](N)CC(=O)O
(S)-3-Amino-3-o-tolyl-propionic acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

This synthesis is carried out by combination of 5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid and (S)-3-Amino-3-o-tolyl-propionic acid applying General Procedure A.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08962671B2uspto-grants-2015_02