反応 #1929062

反応方程式

HCl

potassium hydrogen carbonate

6-(chloracetamido) hexanoic acid

potassium cyanide

→

6-(cyanacetamido)hexanoic acid

溶媒

water

反応条件

後処理

1. 1
   温度was cooled on ice
2. 2
   抽出The residue after extraction
3. 3
   その他was purified by chromatography (silica gel, solvent: ethyl acetate)

実験手順

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

出典