反応 #1929054

ord-9e82479849424fd6ac2d50e6fd3911e4

反応方程式

COC(=O)CCCCCCCCCCCCCCCBr
16-bromohexadecanoic acid methyl ester
[N-]=[N+]=[N-].[Na+]
sodium azide
→
COC(=O)CCCCCCCCCCCCCCCN=[N+]=[N-]
azide
COC(=O)CCCCCCCCCCCCCCCN=[N+]=[N-]
16-azidohexadecanoic Acid Methyl Ester

反応物

COC(=O)CCCCCCCCCCCCCCCBr
16-bromohexadecanoic acid methyl ester
[N-]=[N+]=[N-].[Na+]
sodium azide

試薬

なし

溶媒

CC#N
acetonitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    温度at reflux temperature

実験手順

16-bromohexadecanoic acid methyl ester is reacted with sodium azide in acetonitrile for four days at reflux temperature to give the corresponding azide (Zinic et al., Positionally Isomeric Organic Gelators: Structure-Gelation Study, Racemic versus Enantiomeric Gelators, and Solvation Effects, Chem. Eur. J. 2010; 16:3066-82).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08945897B2uspto-grants-2015_02