反応 #1929022

反応方程式

Benzoyl chloride

3-Nitrophenol

triethylamine

water

→

3-nitrophenyl benzoate

収率 90.3%

溶媒

dichloromethane

反応条件

後処理

1. 1
   workup.STIRRINGthe resulting solution was shaken at room temperature until full conversion
2. 2
   乾燥The organic phase was dried over magnesium sulfate
3. 3
   ろ過filtered
4. 4
   その他the solvent was removed under reduced pressure

実験手順

3-Nitrophenol (1.716 g, 12.346 mmol) and triethylamine (1.6 mL, 12.346 mmol) were dissolved in 50 mL of dichloromethane. The solution was shaken 30 minutes at room temperature. Benzoyl chloride (1.43 mL, 12.346 mmol) was added drop by drop and the resulting solution was shaken at room temperature until full conversion as determined by thin-layer chromatography. Carbonated water (20 mL) was added three times. The organic phase was dried over magnesium sulfate, filtered and the solvent was removed under reduced pressure, thus affording 2.7080 g of a white solid corresponding to 3-nitrophenyl benzoate (11.144 mmol, yield=90%).

出典