反応 #1929010

反応方程式

sodium bisulfite

sodium indole-2-sulfonate

acetic anhydride

→

sodium 1-acetylindole-2-sulfonate

収率 93.0%

反応条件

後処理

1. 1
   温度The mixture was heated
2. 2
   workup.WAITat 90° C. for 2 hrs
3. 3
   温度Upon cooling
4. 4
   ろ過the solid was filtered
5. 5
   洗浄washed with ether
6. 6
   その他dried

実験手順

To a round-bottom-flask containing 60 mL acetic anhydride was added 5 g sodium bisulfite and 5 g sodium indole-2-sulfonate. The mixture was heated and stirred at 70° C. for 1 hr and then at 90° C. for 2 hrs. Upon cooling, the solid was filtered, washed with ether, and dried to yield 5.7 g of sodium 1-acetylindole-2-sulfonate product (93%) as a white solid. The sodium 1-acetylindole-2-sulfonate product was used in the next step without further purification. MP>320° C.; IR (KBr, cm−1) 3480, 3010, 1660, 1490, 1400, 1385, 1150, 1050, 980, 760.

出典