反応 #1929003

反応方程式

Sodium borohydride

( 28 )

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

→

crude compound ( 29 )

収率 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-ol

収率 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

溶媒

MeOH

反応条件

後処理

1. 1
   温度with chilling on ice
2. 2
   温度with chilling on ice, its solvent
3. 3
   その他was evaporated under reduced pressure
4. 4
   workup.ADDITIONWater was added to its residue, which
5. 5
   抽出was then subjected to extraction with methylene chloride
6. 6
   乾燥by drying its organic layer with anhydrous magnesium sulfate
7. 7
   その他Its solvent was evaporated under reduced pressure

実験手順

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one (28) was synthesized according to a method described in J. Med. Chem. 1994, 37, 2831-2840. Sodium borohydride (1.49 g) was added into the MeOH (80 ml) solution of (28) (6.75 g) with chilling on ice. After its mixture was stirred for 1 hour with chilling on ice, its solvent was evaporated under reduced pressure. Water was added to its residue, which was then subjected to extraction with methylene chloride, followed by drying its organic layer with anhydrous magnesium sulfate. Its solvent was evaporated under reduced pressure to produce a crude compound (29) (6.52 g).

出典