反応 #1929

反応方程式

methyl (Z)-3-(3-nitrostyryl)-2-thiophenecarboxylate

acetic anhydride

→

methyl (Z)-3-(3-acetamidostyryl)-2-thiophenecarboxylate

収率 91.3%

反応条件

実験手順

Substantially the same procedure as in Reference Example 14 was repeated using methyl (Z)-3-(3-nitrostyryl)-2-thiophenecarboxylate obtained in Reference Example 13 (3.51 g, 12.1 mmol), and also using acetic anhydride (3.43 ml, 36.3 mmol) instead of trimethylacetyl chloride, to give methyl (Z)-3-(3-acetamidostyryl)-2-thiophenecarboxylate (3.33 g, 2 steps, 91.3%).

出典