反応 #1925199

反応方程式

4-bromo-2-(trifluoromethoxy)iodobenzene

2-[4-(3-methyl-3-hydroxybutyne-1-yl)phenoxy]ethanol

→

2-(4-{2-[4-bromo-2-(trifluoromethoxy)phenyl]ethynyl}phenoxy)ethanol

収率 82.0%

溶媒

triethylamine

反応条件

後処理

1. 1
   その他A flask equipped with a stirrer
2. 2
   温度under reflux for 6 hours
3. 3
   ろ過After the insolubles were filtered off
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   workup.ADDITIONethyl acetate was added to the resulting distillate, and the pH
6. 6
   抽出ethyl acetate extraction
7. 7
   抽出The resulting extract
8. 8
   洗浄was washed with NaCl saturated water
9. 9
   乾燥dried over anhydrous sodium sulfate
10. 10
    ろ過filtered
11. 11
    濃縮concentrated
12. 12
    その他to thereby obtain 3.85 g of a crude product in the form of a yellowish brown solid
13. 13
    その他The crude product was then purified by silica gel column chromatography

実験手順

A flask equipped with a stirrer and a thermometer was charged with 3.35 g (9.13 mmol) of 4-bromo-2-(trifluoromethoxy)iodobenzene and 19 ml of triethylamine under a nitrogen atmosphere. Then 1.48 g (9.13 mmol) of 2-[4-(3-methyl-3-hydroxybutyne-1-yl)phenoxy]ethanol, 13.7 mg (0.072 mmol) of copper (I) iodide, 63.2 mg (0.24 mmol) of triphenylphosphine, and 13.7 mg (0.020 mmol) of dichlorobis(triphenylphosphine)palladium were added at room temperature, and stirred under reflux for 6 hours. After the insolubles were filtered off and the solvent was distilled off, ethyl acetate was added to the resulting distillate, and the pH was adjusted to an acidity with 1N hydrochloric acid to effect ethyl acetate extraction. The resulting extract was washed with NaCl saturated water, dried over anhydrous sodium sulfate, filtered, and concentrated to thereby obtain 3.85 g of a crude product in the form of a yellowish brown solid. The crude product was then purified by silica gel column chromatography using hexane/ethyl acetate as an eluting solvent to obtain 3.0 g of 2-(4-{2-[4-bromo-2-(trifluoromethoxy)phenyl]ethynyl}phenoxy)ethanol in the form of a light yellow solid in a 82% yield.

出典