反応 #1924932

反応方程式

1-[(6-bromo-2-pyridyl)methyl]-4-(2,3-methylenedioxyphenethyl)piperidine

sodium methoxide methanol

Water

→

title compound

1-[(6-Methoxy-2-pyridyl)methyl]-4-(2,3-methylenedioxyphenethyl)piperidine

反応条件

後処理

1. 1
   その他obtained in Referential Example 19
2. 2
   温度by heating
3. 3
   温度under reflux for 1 hour
4. 4
   抽出the mixture was extracted with ethyl acetate
5. 5
   洗浄The extract was washed with brine
6. 6
   乾燥dried over anhydrous magnesium sulfate
7. 7
   その他the solvent was evaporated

実験手順

In a 28% sodium methoxide methanol solution (2 ml) was dissolved 218 mg of 1-[(6-bromo-2-pyridyl)methyl]-4-(2,3-methylenedioxyphenethyl)piperidine obtained in Referential Example 19, followed by heating under reflux for 1 hour. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 144 mg of the title compound as a colorless oil.

出典