反応 #1923611

反応方程式

2-(2-nitrophenyl)isoindole-1,3-dione

→

2-(2-aminophenyl)-isoindole-1,3-dione

収率 40.0%

溶媒

benzene

反応条件

後処理

1. 1
   その他pre-sparged with nitrogen gas
2. 2
   workup.ADDITIONwas added 10% palladium on activated carbon (1.0 g)
3. 3
   ろ過the reaction mixture was filtered over celite
4. 4
   洗浄the filter pad was washed with benzene
5. 5
   濃縮Concentration in vacuo

実験手順

To a suspension of the 2-(2-nitrophenyl)isoindole-1,3-dione (1.0 g, 3.50 mmol) in benzene, pre-sparged with nitrogen gas, was added 10% palladium on activated carbon (1.0 g). The reaction mixture was placed under an atmosphere of hydrogen gas and was vigorously stirred. After 45 minutes, the reaction mixture was filtered over celite and the filter pad was washed with benzene. Concentration in vacuo gave 236 mg (40%) of 2-(2-aminophenyl)-isoindole-1,3-dione as a yellow solid: 1H NMR (300 MHz, DMSO-d6) δ 8.85 (m, 4H), 7.10 (m, 1H), 6.98 (m, 1H), 6.75 (m, 1H), 6.55 (m, 1H).

出典