反応 #1923610

反応方程式

2-nitroaniline

phthalic anhydride

→

2-(2-nitrophenyl)isoindole-1,3-dione

収率 121.2%

溶媒

acetic acid

反応条件

後処理

1. 1
   温度The mixture was then heated
2. 2
   温度at reflux for 20 h
3. 3
   温度Upon cooling
4. 4
   その他a yellow precipitate formed
5. 5
   ろ過was collected by filtration
6. 6
   洗浄The filtrate was washed with acetic acid
7. 7
   その他was dried under a under a stream of air

実験手順

To a mixture of 2-nitroaniline (1 g, 7.23 mmol) in acetic acid (5 mL) was added phthalic anhydride (1.29 g, 8.7 mmol) followed by stirring at ambient temperature for 16 h. The mixture was then heated at reflux for 20 h. Upon cooling, a yellow precipitate formed and was collected by filtration. The filtrate was washed with acetic acid and was dried under a under a stream of air to give 2.35 g (100%) of 2-(2-nitrophenyl)isoindole-1,3-dione: 1H NMR (300 MHz, DMSO-d6) δ8 8.21 (m, 1H), 8.02-7.95 (m, 5H), 7.77 (m, 2H).

出典