反応 #1909789

反応方程式

hydrogen

( 1 )

4-[4-(tert-Butoxycarbonylmethylamino)-1-butenyl]-2-hydroxybenzoic acid methyl ester

→

title compound

収率 95.0%

4-[4-(tert-Butoxycarbonylmethylamino)butyl]-2-hydroxybenzoic acid methyl ester

収率 95.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過After filtering through Celite
2. 2
   濃縮the mixture was concentrated under reduced pressure
3. 3
   その他the residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=4/1 v/v)

実験手順

A solution of the compound (0.845 g) obtained in (1) above in methanol (20 ml) was vigorously stirred in the presence of 10% palladium-carbon (0.106 g) in a stream of hydrogen. After filtering through Celite, the mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=4/1 v/v) to give the title compound (0.810 g, yield 95%).

出典