反応 #1905554

ord-cb46f039e3bb402b8b1e917a89c179cd

反応方程式

O=C(Nc1nc(CBr)cs1)N(C1CCCCC1)C1CCCCC1
1,1-dicyclohexyl-3-(4-bromomethyl-thiazol-2-yl)urea
CCOC(=O)c1c[nH]c(S)n1
2-mercapto-1H-imidazole-4-carboxylic acid ethyl ester
O=C(O)c1c[nH]c(SCc2csc(NC(=O)N(C3CCCCC3)C3CCCCC3)n2)n1
2-[2-(3,3-dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid
CCOC(=O)c1c[nH]c(SCc2csc(NC(=O)N(C3CCCCC3)C3CCCCC3)n2)n1
2-[2-(3,3-Dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid ethyl ester
収率 20.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

2-[2-(3,3-Dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid ethyl ester was prepared in 20% yield as described in general procedure L from 1,1-dicyclohexyl-3-(4-bromomethyl-thiazol-2-yl)urea and 2-mercapto-1H-imidazole-4-carboxylic acid ethyl ester. The ester (30 mg, 0.06 mmol) was hydrolysed using general procedure F to give 2-[2-(3,3-dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid in 80% yield (22 mg).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07598391B2uspto-grants-2009_10