反応 #1904601

反応方程式

(1S)-1-phenylpropylamine

triethylamine

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline

triphosgene

→

title compound

収率 121.9%

N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(1S)-1-phenylpropyl]urea

収率 121.9%

溶媒

chloroform

chloroform

chloroform

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 10 hr
2. 2
   その他The stirred mixture was purified by chromatography on silica gel

実験手順

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (70 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (33 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for 75 min. Next, a solution of (1S)-1-phenylpropylamine (31 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (62 mg, yield 57%).

出典