反応 #1904065

反応方程式

1-(2-amino-5-bromo-phenyl)-ethanone

sodium borohydride

→

title compound

収率 86.8%

1-(2-Amino-5-bromo-phenyl)-ethanol

収率 86.8%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONpoured onto ice water
2. 2
   抽出extracted with ethyl acetate (3×30 mL)
3. 3
   乾燥The combined organic layers were dried (MgSO4)
4. 4
   濃縮concentrated

実験手順

To a solution of 1-(2-amino-5-bromo-phenyl)-ethanone (2.4 g, 11.2 mmol) in anhydrous methanol (50 mL) was added sodium borohydride (1 g, 26 mmol) at rt under nitrogen. The mixture was stirred for 1 h, poured onto ice water, and extracted with ethyl acetate (3×30 mL). The combined organic layers were dried (MgSO4) and concentrated to yield the title compound as an off-white solid (2.1 g, 86%): mp 95-96° C.

出典