反応 #1904042

反応方程式

4-bromostyrene

magnesium

cyanuric chloride

→

2,4-dichloro-6-(4-vinylphenyl)-1,3,5-triazine

溶媒

THF

THF

反応条件

後処理

1. 1
   その他A solution formed
2. 2
   温度refluxed for two hours
3. 3
   workup.STIRRINGthe mixture was stirred at −20° C. for five hours
4. 4
   workup.DISTILLATIONThe solvent was distilled off under a reduced pressure
5. 5
   workup.DISSOLUTIONthe remaining solid was dissolved into dichloromethane
6. 6
   洗浄washed with water twice
7. 7
   乾燥The organic layer was dried over anhydride MgSO4
8. 8
   workup.DISTILLATIONthe solvent was distilled off

実験手順

A solution formed by dissolving 4-bromostyrene (18.3 g, 0.1 mol) and magnesium (2.64 g, 0.11 mol) into THF (200 mL) was stirred at 30° C. for two hours, and then, refluxed for two hours. This solution was added to a solution of cyanuric chloride (21.58 g, 0.120 mol) into THF (200 mL) at −20° C., and the mixture was stirred at −20° C. for five hours. The solvent was distilled off under a reduced pressure, the remaining solid was dissolved into dichloromethane and washed with water twice. The organic layer was dried over anhydride MgSO4, and the solvent was distilled off.

出典