反応 #1904035

反応方程式

L-lysine

succinic anhydride

triethyl amine

→

Lysine Succinimide

溶媒

N,N-dimethyl formamide

反応条件

後処理

1. 1
   温度At the end of 6 h period, the solution is cooled
2. 2
   その他solvent is removed by vacuum distillation
3. 3
   その他The crude product is purified by flash chromatography
4. 4
   その他It is then immediately used in next reaction

実験手順

In this example that demonstrates how this method could be performed, 2 g of L-lysine is dissolved in 200 ml dry N,N-dimethyl formamide (DMF) in a 500 ml round bottom flask. 10.7 g succinic anhydride and 20 ml triethyl amine are added under nitrogen atmosphere. The mixture is heated to 60° C. for 6 h. At the end of 6 h period, the solution is cooled and solvent is removed by vacuum distillation. The crude product is purified by flash chromatography. It is then immediately used in next reaction.

出典