反応 #1903

反応方程式

4-bromo-3-methoxyphenol

benzyl bromide

potassium carbonate

→

4-benzyloxy-2-methoxybromobenzene

溶媒

acetone

反応条件

後処理

1. 1
   その他The insoluble materials were removed by filtration
2. 2
   濃縮the filtrate was concentrated in vacuo
3. 3
   その他The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1)

実験手順

A mixture of 4-bromo-3-methoxyphenol (21 g), benzyl bromide (13.5 ml), potassium carbonate (21.4 g) and acetone (200 ml) was stirred at room temperature for 24 h. The insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give 4-benzyloxy-2-methoxybromobenzene (25 g) as an oil.

出典