反応 #1894472

反応方程式

Thionyl chloride

4-(4-AMINOPHENYL)BUTYRIC ACID

methanol

→

methyl 4-(4-aminophenyl)butanoate

収率 94.0%

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
3. 3
   洗浄washed with sat. NaHCO3, water, and sat. NaCl
4. 4
   乾燥dried over Na2SO4
5. 5
   濃縮concentrated

実験手順

Thionyl chloride (2.5 mL, 4.08 g, 34.3 mmol) was added to stirred anhydrous methanol (10 mL) at 0° C. After 20 mins, 4-(4-AMINOPHENYL)BUTYRIC ACID (1.85 g, 10.3 mmol, Aldrich) was added and the mixture was stirred at rt for 16 hrs. The reaction mixture was concentrated and the residue dissolved in ethyl acetate, washed with sat. NaHCO3, water, and sat. NaCl, dried over Na2SO4 and concentrated to give methyl 4-(4-aminophenyl)butanoate (1.88 g, 94%) as a light brown solid.

出典