反応 #1889992

反応方程式

Ethyl 7-nitroindole-2-carboxylate

lithium hydroxide hydrate

hydrochloric acid

→

7-nitro-1H-indole-2-carboxylic acid

溶媒

tetrahydrofuran

water

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   抽出The mixture was extracted with ethyl acetate
3. 3
   乾燥The extract was dried over anhydrous magnesium sulfate
4. 4
   ろ過filtered
5. 5
   workup.DISTILLATIONThe filtrate was distilled under reduced pressure

実験手順

Ethyl 7-nitroindole-2-carboxylate (500 mg, 2.14 mmol) was dissolved in a solvent mixture of tetrahydrofuran and water (1:1, 20 ml), and lithium hydroxide hydrate (448 mg, 10.7 mmol) was added. The mixture was stirred for 8 h at room temperature, and 1N-hydrochloric acid solution was added thereto. The mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was distilled under reduced pressure to give 7-nitro-1H-indole-2-carboxylic acid.

出典