反応 #1889

反応方程式

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

収率 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

収率 95.7%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   その他After reaction
2. 2
   その他the organic layer was dried
3. 3
   その他after which the solvent was removed
4. 4
   その他the residue was recrystallized from hexane

実験手順

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

出典