反応 #1886

反応方程式

water

2-amino-5-chloro-2',4',6'-trimethoxybenzophenone

lithium aluminum hydride

→

crystal

収率 96.1%

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

収率 96.1%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   抽出the solution was extracted with ethyl acetate
2. 2
   乾燥dried over anhydrous sodium sulfate
3. 3
   その他after which the solvent was removed

実験手順

To a solution of 3.0 g of 2-amino-5-chloro-2',4',6'-trimethoxybenzophenone in 50 ml of tetrahydrofuran, 0.43 g of lithium aluminum hydride was added, followed by stirring for 1 hour. After water was added, the solution was extracted with ethyl acetate and dried over anhydrous sodium sulfate, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 2.9 g of a crystal.

出典