反応 #1885028

ord-ec09aff7e7334a79b089e2aa1ba25fbc

反応方程式

CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)ON1C(=O)CCC1=O
Boc-Pro-Pro-OSu
CC[C@H](C)[C@H](N)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Ile Hydrocodone
→
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Pro-Pro-Ile Hydrocodone

反応物

CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)ON1C(=O)CCC1=O
Boc-Pro-Pro-OSu
—
amino acid
CC[C@H](C)[C@H](N)C(=O)O.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Ile Hydrocodone

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Pro-Pro-Ile-Hydrocodone was prepared by a similar method to Example 41 except the amino acid starting material was Boc-Pro-Pro-OSu and the conjugate starting material was Ile-Hydrocodone.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08343927B2uspto-grants-2013_01