反応 #1876815

反応方程式

Boron tribromide

Compound ( e )

4-ethoxy-2-trifluoromethylphenol

→

Compound ( g )

収率 63.2%

2-trifluoromethylhydroquinone

収率 63.2%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   workup.ADDITIONwas slowly added dropwise at the same temperature
2. 2
   抽出the aqueous layer was extracted with ether
3. 3
   洗浄washed with saturated aqueous sodium chloride
4. 4
   乾燥dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

実験手順

Boron tribromide (11.8 g) was slowly added dropwise to dichloromethane (41 mL) cooled to −78° C., and then Compound (e) (6.47 g) dissolved in dichloromethane (60 mL) was slowly added dropwise at the same temperature and the mixture was stirred at room temperature for 2 hours. The reaction mixture was then poured into ice water and the aqueous layer was extracted with ether. The organic layers were combined, washed with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 3.53 g of Compound (g).

出典