反応 #1876812

反応方程式

Bromine

Compound ( b )

3-ethoxybenzotrifluoride

Water

→

Compound ( c )

収率 76.9%

2-bromo-5-ethoxybenzotrifluoride

収率 76.9%

溶媒

ether

反応条件

後処理

1. 1
   抽出the aqueous layer was extracted three times with ether
2. 2
   洗浄washed with saturated aqueous sodium bicarbonate and water
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

実験手順

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

出典