反応 #1876811

反応方程式

Potassium carbonate

methyl ethyl ketone

ethyl iodide

MEK

3-trifluoromethylphenol

→

Compound ( b )

3-ethoxybenzotrifluoride

溶媒

water

反応条件

後処理

1. 1
   温度the reaction mixture was heated
2. 2
   その他to room temperature
3. 3
   抽出the aqueous layer was extracted three times with diethyl ether
4. 4
   洗浄washed with an 1 M aqueous sodium hydroxide solution
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

実験手順

Potassium carbonate (22.6 g) and then a mixture of methyl ethyl ketone (MEK) (150 mL) and ethyl iodide (47.8 g) were added to a mixture of MEK (310 mL) and 3-trifluoromethylphenol (a) (25.0 g) at room temperature, and the reaction mixture was heated and stirred for 2 hours. After returning the mixture to room temperature, water was added for liquid separation and the aqueous layer was extracted three times with diethyl ether. The organic layers were combined, washed with an 1 M aqueous sodium hydroxide solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 19.3 g of Compound (b).

出典