反応 #1869221

反応方程式

1,8-diazabicyclo[5.4.0]undec-7-ene

7-chloro-6-(2,5-dimethylpyrrol-1-ylamino)-1-ethyl-4-oxo-1,4-dihydroquinolonecarboxylic acid

chloromethyl pivalate

→

pure product

2,2-Dimethylpropionyloxymethyl 7-chloro-6-(2,5-dimethylpyrrol-1-ylamino)-1-ethyl-4-oxo-1,4-dihydroquinolone-3-carboxylate

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他reaction
2. 2
   その他at room temperature
3. 3
   その他for 5 days
4. 4
   ろ過The resulting precipitate was filtered off with suction

実験手順

18 μl of 1,8-diazabicyclo[5.4.0]undec-7-ene were added to a solution of 21 mg of 7-chloro-6-(2,5-dimethylpyrrol-1-ylamino)-1-ethyl-4-oxo-1,4-dihydroquinolonecarboxylic acid (Example 36) in 3 ml of acetonitrile and stirred at room temperature for 30 minutes. Then 36 μl of chloromethyl pivalate were added, and reaction was allowed to take place at room temperature for 5 days. The resulting precipitate was filtered off with suction to afford 3.3 mg of pure product.

出典