反応 #1869218

反応方程式

Water

Salicylaldehyde

(2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate

Cs2CO3

→

subtitle compound

収率 114.8%

2-[(2S)-oxiran-2-ylmethoxy]benzaldehyde

収率 114.8%

溶媒

DMF

反応条件

後処理

1. 1
   抽出the mixture was extracted with DCM (2×50 ml)
2. 2
   洗浄The combined organic extracts were washed with water (2×50 ml)
3. 3
   その他The volatiles were removed in vacuo

実験手順

Salicylaldehyde (486 mg, 3.99 mmol) and (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (900 mg, 3.47 mmol) was dissolved in DMF (5 ml) and Cs2CO3 (1.28 g, 3.94 mmol) was added. The reaction mixture stirred for 12 at room temperature. Water (100 ml) was added, and the mixture was extracted with DCM (2×50 ml). The combined organic extracts were washed with water (2×50 ml). The volatiles were removed in vacuo to give the subtitle compound (76%, 710 mg), which was used directly in the next step.

出典