反応 #1869204

反応方程式

malononitrile

ammonium acetate

acetic acid

ethyl 2-(isobutyryl)acetate

→

ethyl 4,4-di-cyano-3-isopropylbut-3-enoate

溶媒

water

toluene

反応条件

後処理

1. 1
   その他for 1 hour

実験手順

1.2 30 g of malononitrile, 3.3 g of ammonium acetate and 4 ml of acetic acid are added to a solution of 55 g of ethyl 2-(isobutyryl)acetate (“AA”) in 210 ml of toluene, and the mixture is boiled at 130° for 1 hour on a water separator. Conventional work-up gives 41.0 g of ethyl 4,4-di-cyano-3-isopropylbut-3-enoate (“AB”), boiling point 95-99° at 0.4 mbar.

出典