反応 #1869203

反応方程式

cis-4-tert-Butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylic acid benzyl ester

→

white solid

収率 100.5%

cis-(3-Hydroxy-piperidin-4-yl)-carbamic acid tert-butyl ester

収率 100.5%

溶媒

methanol

反応条件

後処理

1. 1
   その他was degassed
2. 2
   workup.ADDITIONPearlman's catalyst (palladium hydroxide on carbon, 20wt % Pd (dry basis), ≦50% water, 500 mg) was added
3. 3
   その他the mixture was purged with hydrogen
4. 4
   その他The mixture was degassed with argon
5. 5
   ろ過filtered through a pad of Celite
6. 6
   その他evaporated to dryness

実験手順

10.0 g of cis-4-tert-Butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylic acid benzyl ester slow running Isomer 2 (10b), was dissolved in methanol (350 mL) and was degassed. Pearlman's catalyst (palladium hydroxide on carbon, 20wt % Pd (dry basis), ≦50% water, 500 mg) was added and the mixture was purged with hydrogen and stirring continued under a balloon of hydrogen for 12 hours. The mixture was degassed with argon, filtered through a pad of Celite, and evaporated to dryness to afford 6.2 g (100%) of a white solid.

出典