反応 #1869200

反応方程式

5-benzyloxy-2-hydroxymethyl-4-pyrone

Kojic acid

ammonia

Erol

→

5-Benzyloxy-2-hydroxymethyl-1 H-pyridin-4-one

溶媒

ethanol

反応条件

後処理

1. 1
   温度to reflux overnight
2. 2
   ろ過then filtered
3. 3
   洗浄The resultant solid was washed with ether
4. 4
   その他dried in vacuo (5.9 g)

実験手順

A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 mL), and ethanol (20 mL) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g).

出典