反応 #1869197

反応方程式

2,3-dihydro-benzo[1,4]dioxin-6-ylamine

N-bromosuccinimide

→

oil

収率 93.0%

7-Bromo-2,3-dihydro-benzo[1,4]dioxin-6-ylamine

収率 93.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他then evaporated
2. 2
   workup.DISSOLUTIONThe residue was dissolved in ether
3. 3
   洗浄washed with water
4. 4
   乾燥brine, dried
5. 5
   その他evaporated

実験手順

A solution of 2,3-dihydro-benzo[1,4]dioxin-6-ylamine (1 g, 6.6 mmol) in tetrahydrofuran (15 ml) was cooled to −78 deg C. then treated with 1 drop of concentrated sulphuric acid followed by N-bromosuccinimide (1.2 g, 6.6 mmol). The mixture was allowed to warm to room temperature over 1 hour then evaporated. The residue was dissolved in ether, washed with water then brine, dried and evaporated to afford an oil (1.4 g, 93%).

出典