反応 #1869194

反応方程式

2-chloro-8-benzyloxyquinoline

NaOMe

→

oil

収率 92.0%

8-Benzyloxy-2-methoxyquinoline

収率 92.0%

溶媒

toluene

MeOH

反応条件

後処理

1. 1
   温度The reaction solution was heated
2. 2
   温度After cooling to room temperature
3. 3
   workup.ADDITIONthe reaction solution was poured onto ice
4. 4
   抽出extracted with toluene
5. 5
   乾燥The combined organic extracts were dried (MgSO4)
6. 6
   濃縮concentrated in vacuo

実験手順

The crude 2-chloro-8-benzyloxyquinoline from above was dissolved in toluene (10 mL) and added to a stirred 25 wt % solution of NaOMe in MeOH (50 mL). The reaction solution was heated with stirring overnight at 70° C. After cooling to room temperature, the reaction solution was poured onto ice and extracted with toluene. The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give a colorless oil (6.14 g, 92%). The product was used without further purification.

出典