反応 #1869192

反応方程式

hydroxypyridine

2-Bromo-5-hydroxy-6-nitropyridine

potassium carbonate

Et2O

→

material

収率 89.0%

Ethyl (6-bromo-2-nitro-pyridin-3-yloxy)acetate

収率 89.0%

溶媒

acetone

反応条件

後処理

1. 1
   温度The reaction was heated
2. 2
   温度at reflux for 10 hours
3. 3
   その他The precipitate was removed by suction filtration
4. 4
   濃縮the filtrate was concentrated in vacuo

実験手順

The hydroxypyridine (f) (30 g, 0.14 mol) was suspended in acetone (200 ml), and potassium carbonate (39 g, 0.28 mol) was added, followed by ethyl bromoacetate (15.7 ml, 0.14 mmol). The reaction was heated at reflux for 10 hours, then was cooled to room temperature and diluted with Et2O. The precipitate was removed by suction filtration, and the filtrate was concentrated in vacuo to afford material (38 g, 89%), which was used without further purification.

出典