反応 #1869191

反応方程式

3-Hydroxy-2-nitropyridine

sodium methoxide

bromine

→

material

収率 97.9%

2-Bromo-5-hydroxy-6-nitropyridine

収率 97.9%

溶媒

methanol

methanol

反応条件

後処理

1. 1
   workup.STIRRINGThe reaction was then stirred at 0° C. for 30 minutes
2. 2
   その他was quenched with glacial AcOH (2.5 ml)
3. 3
   その他The solvent was removed in vacuo

実験手順

3-Hydroxy-2-nitropyridine (20 g, 0.143 mole) was dissolved in methanol (400 ml) and a solution of 25% sodium methoxide in methanol (33 ml, 0.13 mol) was added at room temperature. The mixture was stirred for 30 minutes, then cooled to 0° C., and bromine (7.2 ml, 0.14 mol) was added slowly. The reaction was then stirred at 0° C. for 30 minutes, then was quenched with glacial AcOH (2.5 ml). The solvent was removed in vacuo to afford material (30 g, 96%), which was used without further purification.

出典