反応 #1869190

反応方程式

( d )

4-Vinyl-quinoline-6-carbonitrile

piperidin-4-yl-carbamic acid tert-butyl ester

→

product

収率 99.9%

{1-[2-(6-Cyano-quinolin-4-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

収率 99.9%

溶媒

chloroform

反応条件

後処理

1. 1
   その他The product was purified by flash silica chromatography
2. 2
   洗浄eluting with a 0-2% methanol in chloroform gradient

実験手順

A mixture of (d) (150 mg, 0.8 mmol), piperidin-4-yl-carbamic acid tert-butyl ester (166 mg, 0.8 mmol) and chloroform (0.5 ml) were heated at 50° C. in a loosely capped vial for 6 hours. The product was purified by flash silica chromatography eluting with a 0-2% methanol in chloroform gradient affording the product as a foam (304 mg, 96%).

出典