反応 #1869189

反応方程式

( c )

4-Bromo-quinoline-6-carbonitrile

vinyltributyltin

→

product

収率 64.5%

4-Vinyl-quinoline-6-carbonitrile

収率 64.5%

溶媒

toluene

反応条件

後処理

1. 1
   温度the mixture was refluxed under argon for 2 hours
2. 2
   その他Evaporation and flash silica chromatography
3. 3
   洗浄eluting with chloroform

実験手順

To a solution of (c) (1 g, 4.3 mmol) and vinyltributyltin (1.5 mL, 5.17 mmol) in degassed toluene (20 ml) was added tetrakis(triphenylphosphine) palladium (0) (245 mg, 5 mol %) and the mixture was refluxed under argon for 2 hours. Evaporation and flash silica chromatography eluting with chloroform afforded the product as a pale yellow solid (500 mg, 64%).

出典