反応 #1869188

反応方程式

( b )

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

phosphorous tribromide

→

product

収率 87.0%

4-Bromo-quinoline-6-carbonitrile

収率 87.0%

溶媒

—

ice water

DMF

water

反応条件

後処理

1. 1
   ろ過The product was filtered off
2. 2
   洗浄washed with water and air
3. 3
   その他dried

実験手順

To a solution of (b) (12 g, 70.5 mmol) in DMF (75 ml) was added dropwise phosphorous tribromide (8 ml, 84.6 mmol) over five minutes (slightly exothermic). The reaction was allowed to cool to room temperature and was then diluted with ice water (100 ml) and stirred 1 hour then diluted with additional water (300 ml). The product was filtered off, washed with water and air dried to provide 14.3 g of product (87%).

出典