反応 #1869187

反応方程式

Intermediate ( a )

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzonitrile

Dowtherm A

→

gold

収率 94.3%

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

収率 94.3%

溶媒

ether

反応条件

後処理

1. 1
   温度After an additional five minutes at reflux
2. 2
   ろ過The product was filtered off
3. 3
   洗浄thoroughly washed with ether
4. 4
   その他air dried

実験手順

Intermediate (a) (27.5 g, 0.101 mol) was slowly added over five minutes to refluxing Dowtherm A (200 ml). After an additional five minutes at reflux, the mixture was allow to cool to room temperature then ether (200 ml) was added. The product was filtered off, thoroughly washed with ether then air dried to afford the product as a gold coloured solid (16.2 g, 94%).

出典