反応 #1869186

反応方程式

4-amino-benzonitrile

2,2-dimethyl-[1,3]dioxane-4,6-dione

trimethylorthoformate

→

solid

収率 97.0%

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzonitrile

収率 97.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was refluxed for 3 hours
2. 2
   温度After cooling the solid
3. 3
   ろ過was filtered off
4. 4
   洗浄washed with ethanol and air
5. 5
   その他dried

実験手順

A mixture of 4-amino-benzonitrile (12.5 g, 0.106 mol), 2,2-dimethyl-[1,3]dioxane-4,6-dione (18.3 g, 0.127 mol) and trimethylorthoformate (16 ml) in ethanol (100 ml) was refluxed for 3 hours. After cooling the solid was filtered off, washed with ethanol and air dried. The product was obtained as an off-white solid (27.9 g, 97%).

出典