反応 #1869183

反応方程式

trisamine

compound

4-benzyl-3,4-dihydro-5H-spiro[1,4-benzoxazepine-2,4′-piperidin]-5-one

cyclopentylisocyanate

→

4-benzyl-N-cyclopentyl-5-oxo-4,5-dihydro-1H,3H-spiro[1,4-benzoxazepine-2,4′-piperidine]-1′-carboxamide

溶媒

dichloroethane

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring overnight at 25° C.
2. 2
   ろ過the mixture was filtered
3. 3
   濃縮the filtrate was concentrated
4. 4
   その他to give the compound of the present invention

実験手順

To a solution of the compound prepared in Example 30 (0.010 mmol) in dichloroethane (0.7 mL) was added cyclopentylisocyanate (0.020 mmol), the mixture was stirred overnight at 25° C. To the reaction mixture was added PS-trisamine (Argonaut, product number 800229, loading; 4.36 mmol/g) (6.9 mg). After stirring overnight at 25° C., the mixture was filtered and the filtrate was concentrated to give the compound of the present invention having the following physical data.

出典