反応 #1869182

反応方程式

trisamine

compound

4-benzyl-3,4-dihydro-5H-spiro[1,4-benzoxazepine-2,4′-piperidin]-5-one

cyclopentanecarbonylchloride

→

4-benzyl-1′-(cyclopentylcarbonyl)-3,4-dihydro-5H-spiro[1,4-benzoxazepine-2,4′-piperidin]-5-one

溶媒

dichloroethane

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred overnight at 25° C
2. 2
   ろ過The mixture was filtered
3. 3
   濃縮the filtrate was concentrated
4. 4
   その他to give the compound of the present invention

実験手順

To a solution of the compound prepared in Example 30 (0.010 mmol) in dichloroethane (0.7 mL) were added cyclopentanecarbonylchloride (0.020 mmol) and poly(4-vinylpyridine) (2% cross-linked, Aldrich, CAS#9017-40-7) (5.3 mg). The mixture was stirred overnight at 25° C. To the reaction mixture was added PS-trisamine (Argonaut, product number 800229, loading; 4.36 mmol/g) (6.9 mg), and the mixture was stirred overnight at 25° C. The mixture was filtered and the filtrate was concentrated to give the compound of the present invention having the following physical data.

出典