反応 #1869181

反応方程式

compound

4-benzyl-3,4-dihydro-5H-spiro[1,4-benzoxazepine-2,4′-piperidin]-5-one

3-phenylpropanal

→

4-benzyl-1′-(3-phenylpropyl)-3,4-dihydro-5H-spiro[1,4-benzoxazepine-2,4′-piperidin]-5-one

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring overnight
2. 2
   ろ過the mixture was filtered
3. 3
   濃縮the filtrate was concentrated
4. 4
   その他to give the compound of the present invention

実験手順

To a solution of the compound prepared in Example 30 (0.01 mmol) in tetrahydrofuran (0.4 mL) were added 3-phenylpropanal (0.02 mmol) and MP-BH(OAc)3 (Argonaut, product number 800415, loading; 2.25 mmol/g) (13.3 mg). The mixture was stirred overnight at 25° C. To the reaction mixture were added tetrahydrofuran (0.4 mL) and PS-NHNH2 (Argonaut, product number 800272, loading; 3.65 mmol/g) (8.2 mg). After stirring overnight, the mixture was filtered and the filtrate was concentrated to give the compound of the present invention having the following physical data.

出典