反応 #1865466

反応方程式

6-((4-chlorophenyl)(thiazol-2-yl)methyl)quinolin-4-ol

phosphorus tribromide

→

2-((4-bromoquinolin-6-yl)(4-chlorophenyl)methyl)thiazole

溶媒

DMF

反応条件

後処理

1. 1
   その他A red-brown precipitate formed immediately
2. 2
   その他was collected

実験手順

6-((4-chlorophenyl)(thiazol-2-yl)methyl)quinolin-4-ol (500 mg, 1.417 mmol, 1 equip) was dissolved in DMF (4 mL) and phosphorus tribromide (766 mg, 2.834 mmol, 2 equip) was added dropwise. A red-brown precipitate formed immediately and was collected to yield 2-((4-bromoquinolin-6-yl)(4-chlorophenyl)methyl)thiazole which was used in the next step without purification.

出典