反応 #1857547

反応方程式

dichloro methane

sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

methyl iodide

→

desired compound

1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

溶媒

Brine

THF

反応条件

後処理

1. 1
   温度The mixture was then heated for 10 h
2. 2
   温度to reflux
3. 3
   その他the organic phase was dried
4. 4
   その他evaporated
5. 5
   その他to obtain the crude product
6. 6
   その他This was purified by column chromatography

実験手順

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol (0.4 g) was dissolved in THF (10 mL) and sodium hydride (0.03 g) was added. The mixture was stirred for 30 min at room temperature and methyl iodide (0.08 mL) was added. The mixture was then heated for 10 h to reflux. Brine and dichloro methane were added, the organic phase was dried and evaporated to obtain the crude product. This was purified by column chromatography to obtain 0.04 g of the desired compound.

出典