反応 #1857544

反応方程式

Sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

benzylbromide

→

desired compound

収率 68.9%

1-[2-benzyloxy-2-[2-chloro-4-(4-chlorophenoxy)phenyl]propyl]-1,2,4-triazole

収率 68.9%

溶媒

THF

Brine

反応条件

後処理

1. 1
   温度at reflux
2. 2
   抽出the mixture was extracted with dichloro methane (3×)
3. 3
   その他The combined organic phases were dried
4. 4
   ろ過filtered through a silica plug
5. 5
   その他evaporated
6. 6
   その他The crude product was purified by column chromatography

実験手順

Sodium hydride (0.04 g) was added to a solution of 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol (0.5 g) in THF (15 mL). After 30 min benzylbromide (0.27 g) was added and the mixture was stirred for 18 h at reflux. Brine was added and the mixture was extracted with dichloro methane (3×). The combined organic phases were dried, filtered through a silica plug and evaporated. The crude product was purified by column chromatography to yield 0.43 g of the desired compound.

出典