反応 #1852

反応方程式

3-benzyloxy-6-hydroxymethyl-2-iodopyridine

potassium acetate

ethyl acrylate

→

solution

収率 62.0%

Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate

収率 62.0%

溶媒

DMF

water

反応条件

実験手順

To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1 ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.

出典