反応 #1847235

反応方程式

3-(2-biphenylyl)-2-ethylpropionic acid

thionyl chloride

→

coarse product

収率 106.3%

3-(2-biphenylyl)-2-ethylpropionyl Chloride

収率 106.3%

反応条件

後処理

1. 1
   その他To a 300-ml three-necked round flask (equipped with a stirrer tip
2. 2
   温度the contents in the flask were refluxed for 2.5 hours in a nitrogen atmosphere
3. 3
   workup.DISTILLATIONthe unreacted thionyl chloride was distilled off under reduced pressure

実験手順

To a 300-ml three-necked round flask (equipped with a stirrer tip, a Zimroth condenser, a thermometer and a NaOH trap) were fed 39.9 g (157.2 mmol) of 3-(2-biphenylyl)-2-ethylpropionic acid and 77.7 ml (1,065 mmol) of thionyl chloride, and the contents in the flask were refluxed for 2.5 hours in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 45.6 g of a coarse product of an yellow-orange liquid. This acid chloride was used for the next reaction without any further purification.

出典