反応 #1842408

反応方程式

3-isopropylpyrrolo[1,2-a]pyrazin-1(2H)-one

POCl3

→

chloro-3-isopropylpyrrolo[1,2-a]pyrazine

収率 62.0%

反応条件

後処理

1. 1
   その他POCl3 was removed under reduced pressure
2. 2
   洗浄washed twice with saturated sodium bicarbonate
3. 3
   乾燥Afterward the organic phase was dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated under reduced pressure
6. 6
   その他The residue was purified by flash chromatography (SiO2, 5-10% MTBE/hexanes)

実験手順

3-isopropylpyrrolo[1,2-a]pyrazin-1(2H)-one from step b (1.6 g, 4.7 mmol) was combined with POCl3 (20 mL) and stirred at 70° C. for 20 minutes. POCl3 was removed under reduced pressure. The residue was taken up in DCM and washed twice with saturated sodium bicarbonate. Afterward the organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 5-10% MTBE/hexanes) to provide chloro-3-isopropylpyrrolo[1,2-a]pyrazine (1.09 g, 62% yield).

出典