反応 #1838

反応方程式

nitric acid

sulfuric acid

3-trifluoromethoxybenzoic acid

→

2-Nitro-5-trifluoromethoxybenzoic acid

反応条件

後処理

1. 1
   温度while cooling
2. 2
   温度The reaction mixture was heated at 50°-55° C. for 1 hour
3. 3
   温度after cooling
4. 4
   workup.ADDITIONwas poured onto ice
5. 5
   ろ過the residue was filtered off with suction
6. 6
   その他to give
7. 7
   その他after drying
8. 8
   その他8.8 g of product, melting point 90°-93° C. (sintering at 85° C.)

実験手順

29.7 ml of nitric acid were added dropwise to 76.5 ml of concentrated sulfuric acid, while cooling and stirring, and 9.0 g (43.7 mmol) of 3-trifluoromethoxybenzoic acid were then added. The reaction mixture was heated at 50°-55° C. for 1 hour and, after cooling, was poured onto ice, and the residue was filtered off with suction to give, after drying, 8.8 g of product, melting point 90°-93° C. (sintering at 85° C.).

出典